It would be a computer I would use for personal use, business use and gaming, so compatibility is extremely important. I'll probably avoid AMD cards for now since I have had so many problems with their drivers in the past. That is my only real requirement. I just haven't had time to do research recently so I'm not sure what some solid Mobos, cases, PSUs, etc. are right now.
I was hesitant about a Ryzen because I worked directly with AMD on a pre-release product while Gen 1 was being developed and...it had problems. Those are probably all cleared up by now, so I'll check it out.
I'd go with a Ryzen gen 3, lots of RAM (but not the fastest) and a medium priced nvidia, a pcie4 ssd and a big hdd for storage. Cases and PSUs are pretty much universal, the choice is on what's important to you.