It would be a computer I would use for personal use, business use and gaming, so compatibility is extremely important. I'll probably avoid AMD cards for now since I have had so many problems with their drivers in the past. That is my only real requirement. I just haven't had time to do research recently so I'm not sure what some solid Mobos, cases, PSUs, etc. are right now.
I tried an R9 270 card and it was a nightmare. Ended up spending more and trading it in for a GTX 960. I know a lot of people seem to like the AMDs but I don't think I'd try it again.