Grand Theft Auto(owned and going to do this in FPS mode if I get around to it)
Souls/Bloodborne(own at least one of these)
Uncharted/Last of Us
Word Of Warcraft
Call Of Duty/Battlefield
Minecraft
To name a few of the big ones.
Plus some others like Sonic, Mortal Kombat/Streetfighter and Pokemon which I haven't played for over 20 years.
Here's a list to give you some idea of what "big" is:
https://en.wikipedia.org/wiki/List_of_best-selling_video_game_franchises
Up until a few months ago, my answer would be the Elder Scrolls series. Never played one until I got a huge urge to play an RPG and bought Morrowind off of GoG. I'm shocked how good of a game it actually is. If you can get past the horribly dated inventory system and you install a few mods to modernize it, then it's a gem to play