Grand Theft Auto(owned and going to do this in FPS mode if I get around to it)
Souls/Bloodborne(own at least one of these)
Uncharted/Last of Us
Word Of Warcraft
Call Of Duty/Battlefield
Minecraft
To name a few of the big ones.
Plus some others like Sonic, Mortal Kombat/Streetfighter and Pokemon which I haven't played for over 20 years.
Here's a list to give you some idea of what "big" is:
https://en.wikipedia.org/wiki/List_of_best-selling_video_game_franchises
I've never played any game or series in which multi-player was the primary mode. I've tried two Final Fantasy games and never gotten far. I've tried two Fallout games and didn't get far.
I've played far too many hours of Mass Effect and Dragon Age, and thanks to EA I may never play another one.