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As seen in Panama and Madison, WI.

Both isthmuses and isthmi are acceptable plural forms.

As seen in [Panama](https://upload.wikimedia.org/wikipedia/commons/4/4b/IsthmusOfPanama.png) and [Madison, WI](https://ecsjets.com/web_images/content/madison.jpg). Both isthmuses and isthmi are acceptable plural forms.

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