I'm sure they tested on mice, rats, rabbits, dogs, etc.. before attempting in humans (testing in humans without first testing in animals and getting results is far too costly). CRISPR is not creating "genetic supermen", in the fact CRISPR technique is limited to only areas of DNA in which the CAS9 mechanism works. Basically with CRISPR (which is very far off from being on the market as a treatment for anything, it's extremely inefficient and expensive at this point without enough actual clinical data) you can get 4 scenarios 1. The gene inserted works as it should creating a healthy patient 2. The gene works as it should for awhile but the patient eventually reverts back to making damaged DNA 3. The gene does not work and is not replicated 4.The gene works however in combination with other genes of the patient it leads to a higher risk for another genetic disease (these scenarios are run extensively before attempting such a procedure as the goal is always to minimize variables and utilize animal models for maximum safety/efficacy, otherwise the data returned could heavily damage chance of approval).
I'm sure they tested on mice, rats, rabbits, dogs, etc.. before attempting in humans (testing in humans without first testing in animals and getting results is far too costly). CRISPR is not creating "genetic supermen", in the fact CRISPR technique is limited to only areas of DNA in which the CAS9 mechanism works. Basically with CRISPR (which is very far off from being on the market as a treatment for anything, it's extremely inefficient and expensive at this point without enough actual clinical data) you can get 4 scenarios 1. The gene inserted works as it should creating a healthy patient 2. The gene works as it should for awhile but the patient eventually reverts back to making damaged DNA 3. The gene does not work and is not replicated 4.The gene works however in combination with other genes of the patient it leads to a higher risk for another genetic disease (these scenarios are run extensively before attempting such a procedure as the goal is always to minimize variables and utilize animal models for maximum safety/efficacy, otherwise the data returned could heavily damage chance of approval).
I'm sure they tested on mice, rats, rabbits, dogs, etc.. before attempting in humans (testing in humans without first testing in animals and getting results is far too costly). CRISPR is not creating "genetic supermen", in the fact CRISPR technique is limited to only areas of DNA in which the CAS9 mechanism works. Basically with CRISPR (which is very far off from being on the market as a treatment for anything, it's extremely inefficient and expensive at this point without enough actual clinical data) you can get 4 scenarios 1. The gene inserted works as it should creating a healthy patient 2. The gene works as it should for awhile but the patient eventually reverts back to making damaged DNA 3. The gene does not work and is not replicated 4.The gene works however in combination with other genes of the patient it leads to a higher risk for another genetic disease (these scenarios are run extensively before attempting such a procedure as the goal is always to minimize variables and utilize animal models for maximum safety/efficacy, otherwise the data returned could heavily damage chance of approval).