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In late 1964, Irish-born guitarist John "Sean" Byrne was sitting in a Health Education class in his freshman year at San Jose City College in California, learning about psychosis and neurosis. His friend Ron Lamb leaned over and whispered: "You know what would be a great name for a song? Psychotic Reaction!". Byrne had been writing a tune in his head that day, and used the title to finish it, with the entire band given writing credit. According to an interview with Byrne, the rave-up solo section of the song was influenced by the Yardbirds' frenzied 1965 treatment of Bo Diddley's R&B classic "I'm A Man", while the rest of the song was contributed by the band.