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"I Can't Quit You Baby" is a blues standard written by Willie Dixon and first recorded by Chicago blues artist Otis Rush in 1956. In his autobiography, Willie Dixon explained that "I Can't Quit You Baby" was written about a preoccupied relationship Rush was having at the time. Dixon used this statement to draw out an impassioned performance by Rush. Rush's original Cobra single was inducted into the Blues Foundation Hall of Fame in 1994, which described it as "a Willie Dixon production revealing Rush as an extraordinary talent with an impassioned approach."