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[–] pembo210 [OP] 0 points (+0|-0)

The newest Smash Childhood Cancer work units will look at two potentially important targets, PRDM14 and Fox01.

PRDM14 is involved in intracranial germ cell tumors (IGCTs) that primarily affect adolescents and young adults. These are very rare brain tumors that have a much higher incidence in Japan and East Asia. In addition to IGCTs, PRDM14 also affects non-small cell lung cancer, breast cancer, leukemia (both pre-B cell and T-cell) as well as prostate cancer.

Fox01 is believed to play a role in the development of a number of cancers in addition to childhood cancers, including prostate, endometrial, pancreatic, and others.