Ok, 2001 Ford F250 with the 7.3 engine. 363,000 miles.
I knew something was going to get me and it turned out to be the tranny. Theses trucks are notorious for transmission problems.
The question is, how much, on average, will a transmission repair cost? The truck is only worth about $6000. Am I totalled?
If manual it's not so bad but at 363k I'd just say give up on it. You're standing on the precipice of a giant money pit unless it's had some serious maintenance and an engine rebuild. A month after you fix the transmission something else big will inevitably go.