Yup, uBlock origin + uMatrix + Decentralyes is a great combination. Some other good additions are addons to block canvas, automatically delete cookies, and switch user agents.
I haven't had to deal with it much since switching to brave and just turning off scripts at home. Any insight for using this on a custom built at a fortune 100 company?
I generally allow 1st party CSS and images on the global scope and work from there. If you don't like micro managing you should probably also allow 1st party scripts but I don't trust most big sites not to sell their tracking so I don't.
This is something i've used since it came out. If anyone wants any tips on it or how to use it with uBlock or Decentraleyes, let me know.